GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs10935120 | 1 | rs4974483 | chr3:134219001 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6 | 3.54E-8 | Height |
| THYM | cis | rs10935120 | 1 | rs4974484 | chr3:134219019 | ANAPC13 | chr3:134196547-134204865:- | 0.59 | 8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs4974484 | chr3:134219019 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 5.87 | 6.33E-8 | Height |
| THYM | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.05 | 2.33E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.81 | 8.19E-8 | Height |
| THYM | cis | rs4974559 | 1 | rs4974559 | chr4:1380848 | CRIPAK | chr4:1385340-1389782:+ | -0.68 | -5.72 | 1.21E-7 | Systolic blood pressure |
| THYM | cis | rs911119 | 1 | rs5030707 | chr20:23618656 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.46 | 2.25E-5 | Chronic kidney disease |
| THYM | cis | rs477692 | 1 | rs503660 | chr10:131418999 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs506274 | chr10:131409392 | MGMT | chr10:131265454-131565783:+ | 0.34 | 4.78 | 6.26E-6 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs508303 | chr10:131424996 | MGMT | chr10:131265454-131565783:+ | -0.3 | -4.28 | 4.48E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs516704 | chr10:131419879 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs522891 | chr10:131430916 | MGMT | chr10:131265454-131565783:+ | -0.32 | -4.48 | 2.06E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs530466 | chr10:131427717 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.62 | 1.23E-5 | Response to temozolomide |
| THYM | cis | rs531676 | 1 | rs531676 | chr10:99637578 | CRTAC1 | chr10:99624758-99790585:- | 0.49 | 4.57 | 1.49E-5 | Metabolic syndrome |
| THYM | cis | rs477692 | 1 | rs538969 | chr10:131410608 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.48 | 2.05E-5 | Response to temozolomide |